A generalized equation for the calculation of receptor noise limited colour distances in n-chromatic visual systems

Researchers must assess similarities and differences in colour from an animal's eye view when investigating hypotheses in ecology, evolution and behaviour. Nervous systems generate colour perceptions by comparing the responses of different spectral classes of photoreceptor through colour opponent mechanisms, and the performance of these mechanisms is limited by photoreceptor noise. Accordingly, the receptor noise limited (RNL) colour distance model of Vorobyev and Osorio (Vorobyev & Osorio 1998 Proc. R. Soc. Lond. B 265, 351?358 (doi:10.1098/rspb.1998.0302)) generates predictions about the discriminability of colours that agree with behavioural data, and consequently it has found wide application in studies of animal colour vision. Vorobyev and Osorio (1998) provide equations to calculate RNL colour distances for animals with di-, tri- and tetrachromatic vision, which is adequate for many species. However, researchers may sometimes wish to compute RNL colour distances for potentially more complex colour visual systems. Thus, we derive a simple, single formula for the computation of RNL distance between two measurements of colour, equivalent to the published di-, tri- and tetrachromatic equations of Vorobyev and Osorio (1998), and valid for colour visual systems with any number of types of noisy photoreceptors. This formula will allow the easy application of this important colour visual model across the fields of ecology, evolution and behaviour.publishersversionPeer reviewe

The importance of side branches of glycosylphosphatidylinositol anchors : a molecular dynamics perspective

Many proteins are anchored to the cell surface of eukaryotes using a unique family of glycolipids called glycosylphosphatidylinositol (GPI) anchors. These glycolipids also exist without a covalently bound protein, in particular on the cell surfaces of protozoan parasites where they are densely populated. GPIs and GPI-anchored proteins participate in multiple cellular processes such as signal transduction, cell adhesion, protein trafficking and pathogenesis of Malaria, Toxoplasmosis, Trypanosomiasis and prion diseases, among others. All GPIs share a common conserved glycan core modified in a cell-dependent manner with additional side glycans or phosphoethanolamine residues. Here, we use atomistic molecular dynamic simulations and perform a systematic study to evaluate the structural properties of GPIs with different side chains inserted in lipid bilayers. Our results show a flop-down orientation of GPIs with respect to the membrane surface and the presentation of the side chain residues to the solvent. This finding agrees well with experiments showing the role of the side residues as active epitopes for recognition of GPIs by macrophages and induction of GPI-glycan-specific immune responses. Protein-GPI interactions were investigated by attaching parasitic GPIs to Green Fluorescent Protein. GPIs are observed to recline on the membrane surface and pull down the attached protein close to the membrane facilitating mutual contacts between protein, GPI and the lipid bilayer. This model is efficient in evaluating the interaction of GPIs and GPI-anchored proteins with membranes and can be extended to study other parasitic GPIs and proteins and develop GPI-based immunoprophylaxis to treat infectious diseases

Reactive direction control for a mobile robot: A locust-like control of escape direction emerges when a bilateral pair of model locust visual neurons are integrated

Locusts possess a bilateral pair of uniquely identifiable visual neurons that respond vigorously to the image of an approaching object. These neurons are called the lobula giant movement detectors (LGMDs). The locust LGMDs have been extensively studied and this has lead to the development of an LGMD model for use as an artificial collision detector in robotic applications. To date, robots have been equipped with only a single, central artificial LGMD sensor, and this triggers a non-directional stop or rotation when a potentially colliding object is detected. Clearly, for a robot to behave autonomously, it must react differently to stimuli approaching from different directions. In this study, we implement a bilateral pair of LGMD models in Khepera robots equipped with normal and panoramic cameras. We integrate the responses of these LGMD models using methodologies inspired by research on escape direction control in cockroaches. Using ‘randomised winner-take-all’ or ‘steering wheel’ algorithms for LGMD model integration, the khepera robots could escape an approaching threat in real time and with a similar distribution of escape directions as real locusts. We also found that by optimising these algorithms, we could use them to integrate the left and right DCMD responses of real jumping locusts offline and reproduce the actual escape directions that the locusts took in a particular trial. Our results significantly advance the development of an artificial collision detection and evasion system based on the locust LGMD by allowing it reactive control over robot behaviour. The success of this approach may also indicate some important areas to be pursued in future biological research

Radiative properties of desert aerosols by optical ground-based measurements at solar wavelengths

Les caractéristiques radiatives des poussières atmosphériques ont été mesurées d'avril à mai 1986 à la station de Mbour (16,9°W; 14,3°N) située à 80 km au sud de Dakar (Sénégal). Couplée avec des mesures satellitaires cette étude présente les premières conclusions des observatoires au sol pendant 15 journées consécutives. L'épaisseur optique varie fortement d'un évènement à l'autre (0,4-2 dans la bande spectrale de 450 mm). Les propriétés radiatives des aérosols sont en accord avec les modèles proposés notamment par SHETTLE's (1984) sur l'impact des brumes sèches sur le bilan énergétique de la planète (Résumé d'auteur

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro

Acknowledgements The authors would like to acknowledge the support of the UHNM theatre staff, Dr. Sana Iftikhar and Dr. Daniel Gey van Pittius for their assistance in acquiring participant lung tissue. Funding Information: This work was supported by funding from the North Staffordshire Medical Institute 50th Anniversary Award and The Royal Society-Newton Mobility Grant. The authors would like to acknowledge the support of the UHNM theatre staff, Dr. Sana Iftikhar and Dr. Daniel Gey van Pittius for their assistance in acquiring participant lung tissue.Peer reviewedPublisher PD

Volcanic Contribution to Decadal Changes in Tropospheric Temperature

Despite continued growth in atmospheric levels of greenhouse gases, global mean surface and tropospheric temperatures have shown slower warming since 1998 than previously. Possible explanations for the slow-down include internal climate variability, external cooling influences and observational errors. Several recent modelling studies have examined the contribution of early twenty-first-century volcanic eruptions to the muted surface warming. Here we present a detailed analysis of the impact of recent volcanic forcing on tropospheric temperature, based on observations as well as climate model simulations. We identify statistically significant correlations between observations of stratospheric aerosol optical depth and satellite-based estimates of both tropospheric temperature and short-wave fluxes at the top of the atmosphere. We show that climate model simulations without the effects of early twenty-first-century volcanic eruptions overestimate the tropospheric warming observed since 1998. In two simulations with more realistic volcanic influences following the 1991 Pinatubo eruption, differences between simulated and observed tropospheric temperature trends over the period 1998 to 2012 are up to 15% smaller, with large uncertainties in the magnitude of the effect. To reduce these uncertainties, better observations of eruption-specific properties of volcanic aerosols are needed, as well as improved representation of these eruption-specific properties in climate model simulations

Collective versus single-particle effects in the optical spectra of finite electronic quantum systems

We study optical spectra of finite electronic quantum systems at frequencies smaller than the plasma frequency using a quasi-classical approach. This approach includes collective effects and enables us to analyze how the nature of the (single-particle) electron dynamics influences the optical spectra in finite electronic quantum systems. We derive an analytical expression for the low-frequency absorption coefficient of electro-magnetic radiation in a finite quantum system with ballistic electron dynamics and specular reflection at the boundaries: a two-dimensional electron gas confined to a strip of width a (the approach can be applied to systems of any shape and electron dynamics -- diffusive or ballistic, regular or irregular motion). By comparing with results of numerical computations using the random-phase approximation we show that our analytical approach provides a qualitative and quantitative understanding of the optical spectrum.Comment: 4 pages, 3 figure

Longitudinal development of antibody responses in COVID-19 patients of different severity with ELISA, peptide, and glycan arrays : an immunological case series

The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A better understanding of its immunogenicity can be important for the development of improved diagnostics, therapeutics, and vaccines. Here, we report the longitudinal analysis of three COVID-19 patients with moderate (1) and mild disease (2 and 3). Antibody serum responses were analyzed using spike glycoprotein enzyme linked immunosorbent assay (ELISA), full-proteome peptide, and glycan microarrays. ELISA immunoglobulin A, G, and M (IgA, IgG, and IgM) signals increased over time for individuals 1 and 2, whereas 3 only showed no clear positive IgG and IgM result. In contrast, peptide microarrays showed increasing IgA/G signal intensity and epitope spread only in the moderate patient 1 over time, whereas early but transient IgA and stable IgG responses were observed in the two mild cases 2 and 3. Glycan arrays showed an interaction of antibodies to fragments of high-mannose and core N-glycans, present on the viral shield. In contrast to protein ELISA, microarrays allow for a deeper understanding of IgA, IgG, and IgM antibody responses to specific epitopes of the whole proteome and glycans of SARS-CoV-2 in parallel. In the future, this may help to better understand and to monitor vaccination programs and monoclonal antibodies as therapeutics

Attribution of Declining Western U.S. Snowpack to Human Effects

Observations show snowpack has declined across much of the western United States over the period 1950–99. This reduction has important social and economic implications, as water retained in the snowpack from winter storms forms an important part of the hydrological cycle and water supply in the region. A formal model-based detection and attribution (D–A) study of these reductions is performed. The detection variable is the ratio of 1 April snow water equivalent (SWE) to water-year-to-date precipitation (P), chosen to reduce the effect of P variability on the results. Estimates of natural internal climate variability are obtained from 1600 years of two control simulations performed with fully coupled ocean–atmosphere climate models. Estimates of the SWE/P response to anthropogenic greenhouse gases, ozone, and some aerosols are taken from multiple-member ensembles of perturbation experiments run with two models. The D–A shows the observations and anthropogenically forced models have greater SWE/P reductions than can be explained by natural internal climate variability alone. Model-estimated effects of changes in solar and volcanic forcing likewise do not explain the SWE/P reductions. The mean model estimate is that about half of the SWE/P reductions observed in the west from 1950 to 1999 are the result of climate changes forced by anthropogenic greenhouse gases, ozone, and aerosols.Lawrence Livermore National Laboratory///Estados UnidosScripps Institution of Oceanography//SIO/Estados UnidosMinistry of Education, Culture, Sports, Science and Technology///JapónCalifornia Energy Commission///Estados UnidosProgram of Climate Model Diagnosis and Intercomparison/[DOE-W-7405-ENG-48]/PCMDI/Estados UnidosUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones Geofísicas (CIGEFI